Important drug interactions and side effects

Warning

Doxycycline

  • Reduced absorption (up to 100%) with iron, calcium, magnesium and some nutritional supplements.
  • Warn patients regarding photosensitivity.

Macrolides (Clarithromycin)

High risk for serious drug interactions (see the BNF or seek pharmacy advice)
Avoid in patients with a prolonged QTc interval.

Quinolones (Ciprofloxacin, Levofloxacin and Ofloxacin)

Patient information leaflet required on prescription.
• Reduced absorption with iron, calcium, magnesium and some nutritional supplements.
• High risk for serious drug interactions (see the BNF or seek pharmacy advice).
• Stop treatment at the first sign of side effects (tendonitis).
• Use with caution in patients over 60 years old.
• Avoid in patients with a prolonged QTc interval.
• Avoid prescribing in combination with corticosteroids.

Editorial Information

Last reviewed: 18/12/2023

Next review date: 18/12/2024

Reviewer name(s): J. Van Aartsen.